Professor Ja Young Moon

Visiting Scholar

Education

  • Ph.D. Biochemistry, Illinois Institute of Technology, 1995
  • M.Sc. Chemistry, Chungang University, 1984
  • B.S. Chemistry, Chungang University, 1982

Research

  • Biochemical, molecular, and toxicological studies on xenobiotic-metabolizing P450-dependent monooxygenases
  • Neurotoxicity of persistent organic pollutants; mining of novel genes expressed by TCDD and PCBs
  • Neurodegeneration studies using animal brain
  • Screening of neuroprotective phytochemicals
  • Prevention and reduction of halogenated environmental organic pollutants toxicities by medicinal phytochemicals
  • Expression and purification of human-derived antimicrobial peptides
  • ER stress: Molecular mechanisms of the unfolded protein response (UPR) through cell-biological, biochemical, and genetic approaches
  • Generation and characterization of mammalian reporter cell lines for both the UPR study and drug screen activating or inhibiting the UPR

Experience

  • Professor, Changwon National University, Department of Biochemistry and Health Sciences, 2004-Present
  • Associate Professor, Changwon National University, Department of Biochemistry and Health Sciences, 1999-2003
  • Visisng Research Professor, University of Michigan, Department of Biological Chemistry, Professor Kaufman, 2009-2011
  • Postdoctoral Research Fellow, University of Michigan, Department of Chemistry, Professor Ramamoorthy, 2004-2005

Publications

  • Moon, J.Y., Kang, D.O., Cho, Y.K., Kong, K.H., Lee, D.K., Ramamoorthy, A. (2011) Characterization of factors favoring the expression and purification of recombinant LL-37 from Escherichia coli. J. Korean Soc. Appl. Biol. Chem. 54(6) In press
  • Lee, H.J., Kwon, H.W., Koh, J.U., Lee, D.K., Moon, J.Y., and Kong, K.H. (2010) An efficient method for the expression and reconstitution of thermostable Mn/Fe superoxide dismutase from Aeropyrum pernix K1. J. Microbiol. Biotechnol. 20(4), 727–731
  • Choi, H.J., Kim, S.A., Kim, D.W., Moon, J.Y., Jeong, Y.K., Joo, W.H. (2008) Characterization of Pseudomonas sp. BCNU171 tolerant to organic solvents. Journal of Basic Microbiology, 48:473-479.
  • Park, H.C., Bae, Y.U., Cho, S.D., Kim, S.A., Moon, J.Y., Ha, K.C., Kim, D.W., Lee, K., Jeong, Y.K., Kwack, D.O., Heo, J.S., Lee, Y.G., Joo, W.H. (2007) Toluene-induced accumulation of trehalose by Pseudomonas sp. BCNU106 through the expression of otsA and otsB homologues. Letters in Applied Microbiology, 44:50-55.
  • Moon, J. Y., Katherine A. Henzler-Wildman, A. Ramamoorthy (2006) Expression and purification of a recombinant LL-37 from Escherichia coli. Biochimica et Biophysica Acta, 1758:1351-1358
  • Moon, J.Y., Lim, H.B., Sohn, H.O., Lee, Y.G., Hak-Chul Hyun, Han-Jae Shin, and Dong-Wook Lee (2006) Regulation of LPS-induced nitric oxide synthase activity by cigarette smoke in mouse brain. J. Toxicol. Pub. Health 22(3):245-251.
  • Kim, E.S., Choi, S.J., Ryu, B.H., Choi, J.H., O, M.S., Park, W.J., Paik, D.H., Ha, K.C., Kang, D.O., Cho, Y.K., Park, K.T., Moon, J. Y. (2006) Protective effects of Hemerocallis fulva extracts on amyloid b-protein-induced death in neuronal cells. J. Korean Oriental Medicine, 27(2): 122-133.
  • Lee, J.Y., Kim, J.W., Lim H.S., Joo, W.H., Cho, Y.K., and Moon, J. Y. (2005) Changes in antioxidant defense systems by 2,2’,5,5’-tetrachlorobiphenyl exposure in neuronal SK-N-MC cells. Toxicology Letters, 157: 139-149
  • Kim, E.S., Choi, S.J., Lee, C.W., Park, K.T., and Moon, J.Y. (2005) Protective effects of Liliaceae root extracts on amyloid b-protein-induced death in neuronal cells. Cancer Prevention Research, 10(4): 242-250.
  • Lee, J.Y., Kim, J.W., Song, J.E., Kim, Y.H., Choi, K.J., Joo, W.H., Cho, Y.K., and Moon, J.Y. (2004) Protective effect of ginseng extract against apoptotic cell death induced by 2,2’,5,5’-tetrachlorobiphenyl in neuronal SK-N-MC cells. Life Sciences, 75: 1621-1634.
  • Moon, J.Y. (2004) Purification and characterization of ascorbic acid 2-kinase from Flavobacterium devorans ATCC 10829. Biochimie, 86: 151-156.
  • Lee, H.C., Hwang, S.G., Lee, Y.G., Sohn, H.O., Lee, D.W., Hwang, S.Y., Kwak, Y.S., Wee, J.J., Joo, W.H., Cho, Y.K., and Moon, J.Y. (2002) In vivo effects of Panax ginseng extracts on the cytochrome P450-dependent monooxygenase system in the liver of 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed guinea pig. Life Sciences, 71: 759-769.
  • Chung, Y.G., Lee, H.S., Lee, K.A., Joung, O., Oh, W.K., Kim, K.D., Lim, J.S., Moon, J.Y., Cho, Y.K., Park, S.N., and Yoon, D.Y. (2002) The efficacy of Saururus chinensis on cervical cancer cells: The inhibitory effect on the function of E6 and E7 oncogenes of HPV type 16. Yakhak Hoeji, 46(6): 426-432.
  • Hwang, S.G., Lee, H.C., Lee, D.W., Kim, Y.S., Joo, W.H., Cho, Y.K., and Moon, J.Y. (2001) Induction of apoptotic cell death by a p53-independent pathway in neuronal SK-N-MC cells after treatment with 2,2’,5,5’-tetrachlorobiphenyl. Toxicology, 165: 179-188.
  • Lee, H.C., Hwang, S.G., Kang, Y.K., Sohn, H.O., Moon, J.Y., Lim, H.B., Jeon, B.H., and Lee, D.W. (2001) Influence of Protaetia brevitarsis extract on liver damage induced by carbon tetrachloride and ethanol in rats. Korean J. Life Science, 11(5): 405-414.
  • Park, J.U., Hwang, S.G., Moon, J.Y., Cho, Y.K., Kim, D.W., Jeong, Y.K., and Rhee, K.H. (2000) Penetration of Hep-2 and Chinese hamster ovary epithelial cells by Escherichia coli harbouring the invasion-conferring genomic region from Salmonella typhimurium. J. Microbiol. 38(4): 270-274.
  • Hwang, S.G., Park, J.U., Lee, H.C., Joo, W.H., Cho, Y.K., and Moon, J.Y. (2000) Proteolysis of b-catenin in apoptotic Jurkat cells. Korean J. Life Science, 10(1): 57-63.
  • Moon, J.Y., Lim, H.B., Sohn, H.O., Lee, Y.G., and Lee, D.W. (1999) Acetone Enhancement of cumene hydroperoxide-supported microsomal cytochrome P450-dependent benzo(a)pyrene hydroxylation. J. Biochem. Mol. Biol. 32(3): 226-231.
  • Moon, J. Y., Lee, D. W., and Park, K. H. (1998) Inhibition of 7-ethoxycoumarin O-deethylase activity in rat liver microsomes by naturally occurring flavonoids: Structure-activity relationships. Xenobiotica, 28(2): 117-126.
  • Lee, D.W., Lim, H.B., Moon, J.Y., and Park, K.H. (1998) In vitro enhancement of Microsomal cytochrome P450-dependent monooxygenases by organic solvents in rat liver. J. Biochem. Mol. Biol. 31(4): 391-398.
  • Park, C., Moon, J. Y., Cokic, P., and Webster, D. A. (1996) Na+-Translocating cytochrome bo terminal oxidase from Vitreoscilla: Some parameters of its Na+ pumping and orientation in synthetic vesicles. Biochemistry, 35: 11895-11900.
  • Moon, J.Y., and Sohn, H.O. (1997) Pharmacology and Physiology of Nicotine. In: Current Topics in Tobacco Science (The Korean Society of Tobacco Science), pp. 315-336.