Luis Solorio, Ph.D.

Contact

  • soloriol@umich.edu

Education

  • Ph.D., Biomedical Engineering, Case Western Reserve University, 2012.
  • M.S. Biomedical Engineering, Rensselaer Polytechnic Institute, 2007.
  • B.S. Biomedical Engineering and Chemistry, Saint Louis University, 2006.

Research

My current work is focused on the application of engineering principles to help bridge the gaps that exist between laboratory research and clinical practice. Specifically, my research is focused on the development of novel microenvironments to provide specific cues to cancer cells. The systems I have developed can be used to understand the environmental factors that drive phenotypic changes in cancer, how cues within the cellular microenvironment influence those changes, and how those changes affect the response of cancer to therapeutic treatment.

Experience

  • Postdoctoral Research Associate, Department of Radiology, Case Western Reserve University, 2012-2013
  • Graduate Student, Department of Biomedical Engineering, Case Western Reserve University, 2008-2012
  • Graduate Student, Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 2006-2007
  • Undergraduate Researcher, Department of Biomedical Engineering, Saint Louis University, 2005-2006
  • Undergraduate Researcher, Department of Molecular Microbiology and Immunology, Saint Louis University, 2004-2005

Awards

  • Department of Defense Breast Cancer Research Program Postdoctoral Fellowship Award, 2013-Current
  • National Institutes of Health Cancer Pharmacology Training Program, 2012
  • National Institutes of Health Interdisciplinary Biomedical Imaging Training Program, 2007-2008
  • Biomedical Engineering Society Undergraduate Research Award, 2006
  • Saint Louis University Outstanding Senior Award, 2006
  • Saint Louis University Sigma Xi Research Symposium First Place Poster, 2006

Publications

  • L. Solorio, D. Sundarapandiyan, A. Olear, A.A. Exner. "The Effect of Additives on the Behavior of Phase Sensitive In Situ Forming Implants", J. Pharm. Sci. (2015), 104(10):3471-3480.
  • L. Solorio, A.A. Exner. "Effect of the Subcutaneous Environment on Phase-Sensitive In Situ-Forming Implant Drug Release, Degradation, and Microstructure", J. Pharm. Sci. (2015). 104(12):4322-4328.
  • Krupka TM, Solorio L, Wilson RE, Wu H, Exner AA. Formulation and characterization of echogenic lipid-pluronic nanobubbles. Molecular Pharmaceutics, 2010;7(1):49-59.
  • Solorio L, Babin BM, Patel RB, Mach J, Exner AA. Noninvasive characterization of in situ forming implants using ultrasound and image analysis. Journal of Controlled Release, 2010;143(2):183-90.
  • Solorio L, Patel RB, Wu H, Krupka T, Exner AA. Advances in image guided interventional oncology. Therapeutic Delivery, 2010;1(2):307-22.
  • Patel RB, Carlson A, Solorio L, Exner AA. Characterization of formulation parameters affecting low molecular weight drug release from in situ forming drug delivery systems. Journal of Biomedical Materials Research, 2010;94(2):476-84.
  • Sandhu GS, Solorio L, Broome AM, Shah T, Salem N, Kolthammer J, Duerk JL. Whole animal imaging. WIREs Systems Biology and Medicine, 2010;2(4):398-421.
  • Solorio L, Zwolinski C, Lund A, Farrell M, Stegemann JP. Gelatin microspheres crosslinked with genipin for local delivery of growth factors. Journal of Tissue Engineering and Regenerative Medicine, 2010;4(7):514-23.
  • Patel RB*, Solorio L*, Wu H, Krupka T, Exner AA. Effect of injection site on in situ implant formation and drug release in vivo. Journal of Controlled Release, 2010;147(3):350-8. * indicates equal contribution
  • Wu H, Krupka T, Patel RB, Solorio L, Exner AA. Differentiation of benign periablational enhancement from residual tumor following radiofrequency ablation using contrast-enhanced ultrasonography in a rat subcutaneous tumor model. Radiology, Ultrasound in Medicine and Biology, 2012;38(3):443-53.
  • Solorio L, Olear AM, Zhou H, Beiswenger AC, Exner AA. Effect of cargo properties on in situ forming implant behavior determined by noninvasive ultrasound imaging. Drug Delivery and Translational Research, 2012;2(1):45-55.
  • Solorio L, Olear AM, Hamilton JI, Patel RB, Beiswenger AC, Wallace JE, Zhou H, Exner AA. Noninvasive characterization of the effect of varying PLGA moleculuar weight blends on in situ forming implant behavior using ultrasound imaging. Theranostics, 2012; 2(11): 1064-1077.
  • Perera RH*, Solorio L*, Wu H, Gangolli M, Silverman E, Hernandez C, Peiris PM, Broome, AM, Exner AA. Nanobubble ultrasound contrast agents for enhanced delivery of thermal sensitizer to tumors undergoing radiofrequency ablation. Pharmaceutical Research, 2013; [Epub ahead of print] * indicates equal contribution
  • Wu H, Rognin NG, Krupka TM, Solorio L, Yoshiara H, Guenette G, Sanders C, Kamiyama N, Exner AA. Acoustic characterization and pharmacokinetic analysis of new nanobubble ultrasound contrast agents. Ultrasound in Medicine and Biology, 2013; doi: 10.1016/j.ultrasmedbio.2013.05.007.[Epub ahead of print]
  • Solorio L, Exner AA. Applications of ultrasound for image-guided drug delivery in cancer chemotherapy. Therapeutic Delivery, 2013;4(7): 785-789.
  • Solorio L, Solorio LD, Gleeson S, Olear A, Carlson A, Exner AA. Phase inverting polymer systems in drug delivery and medicine. Timothy P. Ehlers and James K. Wilhelm Editors, Polymer Phase Inversion. New York, Nova Publishers. 2011; Ch. 4; 171-203.
  • Solorio L, Carlson AC, Zhou H, Exner AA. Implantable drug delivery systems, Rebecca A. Bader Editor, Engineering Polymer Systems for Improved Drug Delivery. John Wiley & Sons, Inc. 2012; Ch. 10; in press.